Although my kids hadn't seen the Pocoyo cartoon (being a Spanish pre-school animated series, perhaps this wasn't a surprise), they instantly understood the setup here. Hello! Pocoyo, stars a young boy who explores a scarcely populated world. It looks like a cross between the Magic Roundabout and an iPod commercial, but plays like a point and click adventure.
Once I entered a name for each of the kids, I handed them the DS and let them get on with it. My oldest (5) was most proficient at the general navigation. Here, she simply had to tap the screen to move the characters around and double tap to interact with objects. A simple map on the top screen shows you where all the characters and items are.